Immunology: T cell Development Quiz
Preview:
The first gene rearrangement in the double negative stage is of the ___ chain
A. beta chain
B. alpha chain
If the TCR binds strongly to MHC class I or II molecules then ___
A. the T cell survives
B. the T cell dies
Immature T cells
A. thymocytes
B. progenitor cells
Which of the two lineages make the majority of T cells?
A. aB
B. yG
Where do T cells develop?
A. bone marrow
B. thymus
Growth factor that is secreted by thymic stromal cells
A. IL 7
B. IL8
Once the complete T cell receptor is formed then the cell expresses
A. CD4
B. CD8
C. CD4 and CD8
Early T cell precursor development occurs in the ___
A. bone marrow
B. thymus
Which receptor signaling commits the progenitor cell to the T lineage?
A. Notch 1
B. not this
Progenitor cells are not committed to the T lineage when they enter the thymus.
A. TRUE
B. FALSE
When the beta chain is produced, is forms a complex with ___
A. CD4
B. CD3
Which rearrangement is first during the double negative stage?
A. beta chain
B. alpha chain
Notch +1 means the progenitor becomes a
A. T cell
B. B cell
The thymus and the proportion of T cells it produces increases with age.
A. TRUE
B. FALSE
T cells are involved in the ___ immune response.
A. innate
B. adaptive
Which of the following about the thymus is true?
A. the thymus begins to degenerate at the age of 25
B. the thymus begins to degenerate at the age of 1
Where do T cells go through selection and education processes?
A. bone marrow
B. thymus
When does gene rearrangment occur to produce a functional TCR?
A. double negative stages
B. double positive stages
If the TCR binds with HIGH affinity to self antigen then the T cell ____
A. survives
B. dies
Involution of the thymus
A. the thymus steadily decreases with age
B. the thymus steadily increases with age
Notch 1- means the progenitor becomes a
A. T cell
B. B cell
Thymic cells that produce growth factors and ligands that contribute to T cell development.
A. progenitor cells
B. stromal cells
Which of the following statements about the thymus is true?
A. the thymus is fully developed after the age of 1
B. the thymus if fully developed before birth
Thymocytes that lack the TCR but beginning to rearrange their TCR genes
A. double negative thymocytes
B. double positive
T lymphocytes derive from the common myeloid progenitor
A. TRUE
B. FALSE
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