Iron Kinetics Quiz
Preview:
Converts non-heme ferric ions to ferrous ions:
A. Divalent Metal Transporter 1
B. Duodenum-Specific Cytochrome B-like Protein
C. Hephaestin
D. Heme oxygenase
a Female patient with a Total Iron Binding Capacity (TIBC) of 75 umol/L is suggestive of having:
A. NBSB Disorder
B. Sideroblastic Anemia
C. Iron-Deficiency Anemia
D. Thalassemia
What is the percent transferrin saturation for a male patient with total serum iron of 63 mg/dL and TIBC of 420 mg/dL?
Is the answer within the reference value?
A. 15%, outside RV
B. 0.15%, inside RV
C. 0.15% outside RV
D. 15%, inside RV
The total iron-binding capacity (TIBC) of the serum is an indirect measure of which iron-related protein?
A. Ferric Ions
B. Ferritin
C. Transferrin
D. None
Below are several of the many steps in the process from absorption and transport of iron to incorporation into heme.
Place them in proper order.
i. Transferrin picks up ferric iron.
ii. Iron is transferred to the mitochondria.
iii. DMT1 transports ferrous iron into the enterocyte.
iv. Ferroportin transports iron from enterocyte to plasma.
v. The transferrin receptor transports iron into the cell.
A. iii, ii, iv, i, v
B. v, iv, i, ii, iii
C. ii, i, v, iii, iv
D. iii, iv, i, v, ii
70% of total body iron is transported in _______ state to Heme portion of Hemoglobin
A. Cationic trivalent
[Ferrous (Fe3+)]
B. Cationic trivalent
[Ferrous (Fe3+)]
C. Cationic bivalent
[Ferric (Fe2+)]
D. Cationic bivalent
[Ferrous (Fe2+)]
When the body has adequate stores of iron, the hepatocytes sense that and will increase the production of hepcidin.
Iron exported from the enterocyte into the blood is ferrous and must be converted to the ferric form for transport in the blood.
A. First Statement is True, Second Statement is False
B. Second Statement is True, First Statement is False
C. Both Statements are Correct
D. Both Statements are Incorrect
Iron is transported out of macrophages, hepatocytes, and enterocytes by what membrane protein?
A. Ferroprotein
B. Transferrin
C. Transferrin Receptor
D. Ferroportin
E. None
What membrane-associated protein in enterocytes transports non-heme ferrous ions from the intestinal lumen into the enterocytes?
A. Heme Transporter
B. Divalent Metal Transporter 1
C. Ferroportin
D. None
In order to enter Enterocytes, the reduction of Heme Iron (Fe2+ to Fe3+) is facilitated by:
A. Duodenum-Specific Cytochrome B-like Protein
B. Heme Transporter
C. Heme Oxygenase
D. None,
Invalid Question
Converts ferrous ions to ferric ions:
A. Divalent Metal Transporter 1
B. Duodenum-Specific Cytochrome B-like Protein
C. Hephaestin
D. Heme oxygenase
________ in Hepcidin Production enables Ferroportin to transport Iron out.
A. increase
B. decrease
The degradation of Heme in an Enterocyte is facilitated by:
A. Heme Oxidase
B. Heme Oxygenase
C. Heme Transporter
D. None,
Invalid Question
Iron is transported in plasma via:
A. Transferrin
B. Divalent Metal Transporter 1
C. Heme Transporter
D. Duodenal Cytochrome B
E. None
The transfer of iron from the enterocyte into the plasma is REGULATED by:
A. Transferrin
B. Ferroportin
C. Hepcidin
D. Hephaestin
E. None
20-80% of the Bone Marrow Normoblasts have Visible Iron with 1-3 Inclusions.
Erythrocytes and Reticulocytes in Peripheral Blood should not have visible iron.
A. First Statement is True, Second Statement is False
B. Second Statement is True, First Statement is False
C. Both Statements are Correct
D. Both Statements are Incorrect
What is the major metabolically available storage form of iron in the body?
A. Hemosiderin
B. Heme Iron
C. Non-Heme Iron
D. Ferritin
E. None
Ferritin and Hemosiderin in Macrophages and Hepatocytes of Storage Compartment accounts for:
A. 10% Total Body Iron,
0.36g of Iron Content
16% Total Body Iron,
0.68g of Iron Content
C. 68% Total Body Iron,
0.36g of Iron Content
D. 18% Total Body Iron,
0.67g of Iron Content
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