Autoimmune Disease Quiz
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Which of the following best describes “molecular mimicry” in autoimmune diseases?
A. The immune system mistakes self-antigens for microbial antigens
B. The immune system recognizes self-cells as “non-self” due to genetic mutation
C. B cells are activated inappropriately by self-antigens
D. T cells lose the ability to recognize self-tissues
Which of the following is the most characteristic skin manifestation of SLE?
A. Butterfly (malar) rash
B. Hyperpigmentation of the face
C. Vitiligo
D. Alopecia areata
Rheumatoid factor (RF) is an autoantibody directed against:
A. Insulin
B. Fc portion of IgG
C. Myelin basic protein
D. Thyroid-stimulating hormone receptor (TSHR)
Which of the following is a common symptom of Myasthenia Gravis?
A. Muscle rigidity
B. Muscle weakness
C. Hyperreflexia
D. Loss of sensation in extremities
Which of the following autoantibodies is considered most specific for the diagnosis of SLE?
A. Anti-dsDNA antibodies
B. Anti-histone antibodies
C. Anti-Sm (Smith) antibodies
D. Anti-CCP antibodies
Which type of hypersensitivity reaction is associated with Rheumatoid Arthritis?
A. Type I (IgE-mediated)
B. Type II (Antibody-mediated)
C. Type III (Immune complex-mediated)
D. Type IV (Cell-mediated)
Which cells in the pancreas are destroyed in Insulin-Dependent Diabetes Mellitus (IDDM)?
A. Alpha cells
B. Beta cells
C. Delta cells
D. Acinar cells
Which hormone is deficient in Type 1 Diabetes?
A. Cortisol
B. Insulin
C. Glucagon
D. Thyroxine
Which of the following organs is most commonly affected in SLE?
A. Lungs
B. Liver
C. Kidneys (Lupus nephritis)
D. Pancreas
The most specific laboratory marker for Rheumatoid Arthritis is:
A. Anti-nuclear antibody (ANA)
B. Anti-dsDNA antibodies
C. Anti-cyclic citrullinated peptide (anti-CCP) antibodies
D. Rheumatoid factor (RF)
Which of the following cells are primarily attacked in Multiple Sclerosis?
A. T-lymphocytes
B. Oligodendrocytes
C. Schwann cells
D. Red blood cells
The primary treatment for Myasthenia Gravis includes:
A. Acetylcholinesterase inhibitors
B. Insulin injections
C. Beta-blockers
D. Dopamine agonists
Which of the following is a hallmark feature of Hashimoto’s Thyroiditis?
A. Hyperthyroidism
B. Hypothyroidism
C. Addison’s disease
D. Graves’ disease
Which complement proteins are commonly reduced during active SLE due to immune complex consumption?
A. C1q and C1s
B. C2 and C4
C. C3 and C4
D. C9 and C5
Which type of antibodies are commonly found in Hashimoto’s Thyroiditis?
A. Anti-thyroid peroxidase (TPO) antibodies
B. Anti-GAD antibodies
C. Anti-dsDNA antibodies
D. Anti-cardiolipin antibodies