Workup of a 45-year-old woman reveals a lesion in the body of the pancreas that is believed to be an insulinoma. Which of the following findings favors enucleation of the lesion over resection?

A. Concern for metastatic disease

B. A 4-cm insulinoma located in the tail of the pancreas

C. Multiple, small lesions (largest < 2 cm) noted throughout the pancreas D. A 1.2-cm insulinoma located 3 mm from the main pancreatic duct  E. A 0.8-cm insulinoma in the head of the pancreas, 1.5 mm from the duct of Wirsung