Pregabalin binds to the α2δ site, an auxiliary subunit of ...

Pregabalin binds to the α2δ site, an auxiliary subunit of voltage-gated calcium channels in the CNS, inhibiting excitatory neurotransmitter release. The drug has proven effects on focal-onset seizures and more than 90% of pregabalin is eliminated renally. It has no significant effects on drug metabolism and few drug interactions. Dosage adjustments are needed in renal dysfunction

A. Pregabalin

B. Phenytoin

C. Phenobarbital

D. Carbamazepine

Select your answer:

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