Barbiturates and benzodiazepines are anticonvulsant drugs used in the treatment of epilepsy. They both bind to distinct site if the same receptor complex and differentially influence the opening and closing of chloride ion pore. What main characteristic differs the mechanism of action?
A. Barbiturates increase the duration of chloride channel opening.Benzodiazepines increase the frequency of opening.
B. Barbiturates prevent the removal of GABA from the synaptic cleft by blockade of GABA transport and Benzodiazepines are irreversible inhibitors of the mitochondrial enzyme GABA.
C. Barbiturates increase the GABAa receptors and benzodiazepines increases GABAb receptors.
D. Barbiturates increase the frequency of opening.Benzodiazepines increase the duration of chloride channel opening.
Select your answer:
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