What is the potential risk associated with gene-altering therapies for sickle-cell disease?
A. Increased risk of vaso-occlusive crises
B. Development of blood cancers
C. Ineffective production of fetal haemoglobin
D. Loss of natural DNA-repair mechanisms
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What is the potential risk associated with off-target edits in CRISPR–Cas9 therapies?
A. Introduction of unwanted mutations
B. Increased risk of cancer
C. Inadequate genetic diversity in the analysis
D. Insufficient sampling of cells from sickle-cell disease patients
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