Medical Quiz

Molecular Genetics Quiz


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A mutation leading to an early ‘stop’ codon is a …

A. frameshift mutation

B. silent mutation

C. missense mutation

D. nonsense mutation


Cytosine makes up 40% of the nucleotides in a sample of DNA from an organism. Approximately what percentage of the nucleotides in this sample will be thymine?

A. 10%

B. 20%

C. 40%

D. 80%


Adenine bonds with ______________.

A. Guanine

B. Thymine

C. Cytosine

D. Adenine


Which of the following is not a post-transcriptional modification of mRNA?

A. addition of poly-A tail

B. addition of 5′ cap

C. removal of introns

D. removal of exons


Which of the following enzymes is NOT needed in replication?

A. DNA ligase

B. RNA primase

C. DNA polymerase III

D. RNA polymerase


STRUCTURE: What Nitrogenous Base does RNA contain that DNA does not?

A. Thymine

B. Uracil

C. Adenine

D. Love


The replication of DNA is…

A. conservative

B. dispersive

C. semi-conservative

D. random


Which piece of genetic material is double-stranded?

A. DNA

B. mRNA

C. rRNA

D. tRNA


A small circular piece of DNA found in bacteria are called …

A. recombinants

B. vectors

C. plasmids

D. prokaryotes


Which of the following information or processes does gene therapy require?

A. the ability to introduce the normal allele into the patient

B. the knowledge and availability of the defective gene but not the normal allele

C. the ability to express the introduced gene at any time in the tissue site within the patient

D. the ability to introduce a defective allele into a patient


ATTTGAGCC- Original
ATTGAGCC – Mutated
The example above is an example of a

A. Insertion- Frameshift

B. Deletion- Substitution

C. Deletion -Frameshift

D. All of the above


A type of substitution in which no  amino acids change is called 

A. Missense

B. Nonsense

C. Silent

D. Deletion


HISTORY: Took the X-Ray crystallography photographs that revealed that DNA is a Double Helix

A. Rosalind Franklin

B. Linnus Pauling

C. Fredrick Griffeth

D. Martha Chase


STRUCTURE: Nucleotides monomers are made up of a sugar, a phosphate, and a:

A. nitrogenous base

B. nucleic acid

C. cholesterol

D. fatty acid


The process of making an mRNA strand from a DNA template is called

A. Replication

B. Transcription

C. Translation

D. Protein Synthesis


In gel electrophoresis ….

A.  15N is needed to weigh down the DNA samples

B. DNA molecules move towards the negative pole

C. larger molecules travel faster

D. smaller DNA fragments travel faster


The process of using an mRNA to make a protein is called

A. Replication

B. Transcription

C. Translation

D. Cell Division


The two strands in a DNA molecule are held together by …

A. hydrogen bonds

B. phosphodiester bonds

C. covalent bonds

D. ionic bonds


Meselsohn and Stahl’s experiment showed that…

A. DNA is the hereditary material

B. one gene leads to one protein

C. DNA replication is semiconservative

D. the nucleus contains DNA


HISTORY: Discovered that A and T bond together and C and G bond together…

A. Watson and Crick

B. Rosalind Franklin

C. Fredrick Griffeth

D. Erwin Chargaff


How many amino acids could be coded using the sequence 5’AUGCCCGUA3′

A. 1

B. 2

C. 3

D. 4


What is Cas9 and what does it do?

A. a protein enzyme that cuts both strands of DNA at sites specified by an RNA guide

B. a DNA sequence that binds the Cas9 protein

C. an RNA molecule that binds to target DNA via complementary base pairing

D. a viral protein that disrupts bacterial membranes


For a repressible operon to be transcribed, which of the following conditions must occur?

A. A corepressor must be present.

B. RNA polymerase and the active repressor must be present.

C. RNA polymerase must bind to the promoter, and the repressor must be inactive.

D. RNA polymerase must not occupy the promoter, and the repressor must be inactive


Transcription takes place in the 

A. cytoplasm

B. chloroplast

C. nucleus

D. mitochondria


Liver cells differ from skin cells mainly because they…

A. have unique ribosomes.

B. use different genetic codes.

C. contain different genes.

D. express different genes.




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